Urodynamic Effects of Gm-csf Administration in Rats with Spinal Cord Injury-induced Neurogenic Bladder
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چکیده
Hypothesis / aims of study Neurogenic Dysfunction of the bladder in spinal cord injury (SCI) patients is a serious problem in all patients leading to significant morbidity, and regarded as an indicator of neurologic conditions in spinal cord after injury. In this study, we investigated the time-related effect of Granulocyte Macrophage colony-stimulating factor (GM-CSF) on urodynamic parameters including pressure/volume and detrusor overactivity (DO) in rats with SCI.
منابع مشابه
Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review
Neurogenic bladder (NGB) secondary to spinal cord injury (SCI) is accompanied with several complications such as urinary tract deterioration, urinary incontinence, and consequently lower quality of life (QoL), significant morbidities, and occasionally death. Current therapeutic methods have some side effects and there is no treatment for the upper urinary tract injuries. Stem cell therapy is a ...
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AIMS We examined the effect of an E-series prostaglandin 1 (EP1) receptor antagonist on bladder activity using a rat model of spinal cord injury (SCI). METHODS Female Sprague-Dawley rats were used. Six weeks after spinal cord transection, conscious-filling cystometry was performed. We evaluated the urodynamic parameters before and after intravenous (0.1 and 1.0 mg/kg) or intrathecal (0.1 and ...
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Neurogenic bladder is related to various types of neurogenic disease and injury, including cerebrovascular accident, brain tumor, spinal cord injury, and Parkinson's disease. The results of urodynamic study show different types of detrusor and sphincter function. According to these urodynamic results, the physician decides on a treatment plan, such as anticholinergics or alpha-blockers. In the ...
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